Anti-KCNQ3 Antibody APC-051 from Alomone Labs, Ltd.

Product Specs
ItemAnti-KCNQ3 Antibody
CompanyAlomone Labs, Ltd.
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberAPC-051
Brand/TrademarkAlomone Labs Ltd
ReactivityMouse (Tested);Rat (Tested);Human (Predicted)
Conjugate/TagUnconjugated
ApplicationsICC, IF, IHC, IP, WB
FormatLyophilized Powder, Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 5% sucrose, 0.025% NaN3
Quantity1 X 25 mcl, 1 X 50 mcl, 1 X 0.2 ml
ClonalityPolyclonal
HostRabbit
Antibody TypePrimary
Concentration08 mg/ml
PurityAffinity purified on immobilized antigen
IsotypeIgG
ImmunogenSynthetic peptide
Domain/Region/TerminusIntracellular, C-terminus
Gene NameKCNQ3
TargetKCNQ3 (KV7.3) Channel
ValidationAs per applications, See images, contact for clarifications
pH RangepH 7.4

Specifications/Features

starting price for North American orders, for exact pricing view product page

Sequence

AEGEKKEDNRYSDLKTIIC, corresponding to amino acid residues 668-686 of rat KCNQ3

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Alomone Labs, Ltd.

PO Box 4287

Jerusalem 91042

Israel

Phone: +972-2-587-2202
+972-2-587-1101

Company Profile

Website: http://www.alomone.com/

(1) Mir324 knockout regulates the structure of dendritic spines and impairs hippocampal long-term potentiationSci RepDecember 8, 2023Emma V. Parkins, Darrin H. Brager, Jeffrey K. Rymer, John M. Burwinkel, Diego Rojas, Durgesh Tiwari, Yueh-Chiang Hu, Christina Grossmonoclonal (Proteintech Cat# 66,774–1-Ig, RRID:AB_2882120), and KCNQ3 rabbit polyclonal (Alomone Labs Cat# APC-051, RRID:AB_2040103). Antagomirs: For ICV injections of miR-324-5p-specific or scrambled antagomirs, mice

(2) Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant miceNature communicationsJune 15, 2023Oh H, Lee S, Oh Y, Kim S, Kim YS, Yang Y, Choi W, Yoo YE, Cho H, Lee S, et al.solution for 2 h at 37 °C: mouse Ank3 (Sant Cruz Biotechnology, sc-12719, 1:200), rabbit Kv7.3 (Alomone, APC-051, 1:1000), chicken mCherry (Abcam, ab205402, 1:5000), mouse PSD-95 (NeuroMab, 75-028, 1:1000), and mouse

(3) Proteomic-Based Approach Reveals the Involvement of Apolipoprotein A-I in Related Phenotypes of Autism Spectrum Disorder in the BTBR Mouse ModelInternational journal of molecular sciencesDecember 4, 2022Li Q, Shi Y, Li X, Yang Y, Zhang X, Xu L, Ma Z, Wang J, Fan L, Wu L.AB_2561044, 1:1000, Cell Signaling), KCNQ2 (Cat. AGP-065, RRID: AB_2827304, 1:200; Alomone), KCNQ3 (Cat. APC-051, RRID: AB_2040103, 1:200; Alomone), KCNQ5 (Cat. APC-155, RRID: AB_2341038, 1:200; Alomone) β-actin (Cat.

(4) Cannabidiol counters the effects of a dominant-negative pathogenic Kv7.2 variantiScienceOctober 21, 2022Zhan X, Drummond-Main C, Greening D, Yao J, Chen SWR, Appendino JP, Au PYB, Turner RW.anti-Kv7.2 antibody (1:1000, Cell Signaling Tech,14,752), a rabbit anti-Kv7.3 antibody (1:1000, Alomone, APC-051), and a mouse anti-GAPDH antibody (1:1000, Invitrogen, 39–8600). The secondary antibodies used were

(5) Loss-of-function variants in the KCNQ5 gene are implicated in genetic generalized epilepsieseBioMedicineOctober 1, 2022Johanna Krüger et al.experiments were conducted with the stable KV7.3 cell line, an additional primary antibody against KV7.3 (APC-051, Alomone labs) was used. Following this, the membranes were washed and shaken in PBST thrice and then

(6) Heterogeneity of Potassium Channels in Human Embryonic Stem Cell-Derived Retinal Pigment EpitheliumStem Cells Translational MedicineJuly 20, 2022Iina Korkka, Heli Skottman, Soile Nymark(1:100; APC-022; Alomone Labs, Jerusalem, Israel), KCNQ2 (1:100; APC-050; Alomone Labs), KCNQ3 (1:100; APC-051; Alomone Labs), KCNQ4 (1:100; APC-164; Alomone Labs), KCNQ5 (1:100; APC-155; Alomone Labs), cellular

(7) Impaired Kv7 channel activity in the central amygdala contributes to elevated sympathetic outflow in hypertensionCardiovascular researchJanuary 29, 2022Sheng ZF, Zhang H, Zheng P, Chen S, Gu Z, Zhou JJ, Phaup JG, Chang HM, Yeh ETH, Pan HL, et al.

(8) The SUMO-specific protease SENP2 plays an essential role in the regulation of Kv7.2 and Kv7.3 potassium channelsThe Journal of biological chemistryOctober 1, 2021Chen X, Zhang Y, Ren X, Su Q, Liu Y, Dang X, Qin Y, Yang X, Xing Z, Shen Y, et al.

(9) KCNQ Channels in the Mesolimbic Reward Circuit Regulate Nociception in Chronic Pain in MiceNeuroscience bulletinMay 1, 2021Wang HR, Hu SW, Zhang S, Song Y, Wang XY, Wang L, Li YY, Yu YM, Liu H, Liu D, et al.antibodies rabbit anti-Kv7.2 (KCNQ2, 1:100; APC-050, Alomone Labs), rabbit anti-Kv7.3 (KCNQ3, 1:100; APC-051, Alomone Labs), and mouse anti-tyrosine hydroxylase (1:600, 318; Millipore), at 4°C overnight. The sections

(10) Alteration of Mesopontine Cholinergic Function by the Lack of KCNQ4 SubunitFrontiers in cellular neuroscienceJanuary 1, 2021Bayasgalan T, Stupniki S, Kovács A, Csemer A, Szentesi P, Pocsai K, Dionisio L, Spitzmaul G, Pál B.either rabbit anti-KCNQ2 (1:200; #APC-050, Alomone Labs, Jerusalem, Israel), rabbit anti-KCNQ3 (1:100; #APC-051, Alomone Labs, Jerusalem, Israel), rabbit anti-KCNQ4 (1:400), or guinea pig anti-KCNQ5 (1:200) (Spitzmaul

(11) The M-current works in tandem with the persistent sodium current to set the speed of locomotionPLoS biologyNovember 1, 2020Verneuil J, Brocard C, Trouplin V, Villard L, Peyronnet-Roux J, Brocard F.rabbit Kv7.2 (PA1-929, residues 1–70; 1:1,000; Thermo Fisher Scientific, Waltham, MA, USA), Kv7.3 (APC-051, residues 668–686; 1:400; Alomone, Jerusalem, Israel)-specific polyclonal antibody, and mouse pan-Nav

(12) Identifying mutation hotspots reveals pathogenetic mechanisms of KCNQ2 epileptic encephalopathyScientific reportsMarch 16, 2020Zhang J, Kim EC, Chen C, Procko E, Pant S, Lam K, Patel J, Choi R, Hong M, Joshi D, et al.include anti-Kv7.2 (Neuromab, N26A/23), rabbit anti-Kv7.2 (Alomone, APC-050), rabbit anti-Kv7.3 (Alomone, APC-051), anti-GAPDH antibodies (Cell Signaling, 2118), donkey anti-rabbit and anti-mouse HRP secondary antibodies

(13) Heterozygous loss of epilepsy gene KCNQ2 alters social, repetitive and exploratory behaviorsGenes, brain, and behaviorJanuary 1, 2020Kim EC, Patel J, Zhang J, Soh H, Rhodes JS, Tzingounis AV, Chung HJ.were immunoblotted with antibodies for Kv7.2 (1:200, Neuromab cat# 73‐079), Kv7.3 (1:200, Alomone cat# APC‐051) and GAPDH (1:1000, Cell Signaling) as described.54 After incubating in HRP‐conjugated secondary antibodies,

(14) A novel homozygous KCNQ3 loss-of-function variant causes non-syndromic intellectual disability and neonatal-onset pharmacodependent epilepsyEpilepsia openSeptember 1, 2019Lauritano A, Moutton S, Longobardi E, Tran Mau-Them F, Laudati G, Nappi P, Soldovieri MV, Ambrosino P, Cataldi M, Jouan T, et al.first directed against a C‐terminal epitope (rat aa 668‐686; accession number O88944; C‐KCNQ3) (clone APC‐051, dilution 1:1000; Alomone Labs) and (b) the second raised against an N‐terminal epitope (rat aa 1‐71;

(15) Oxytocin Transforms Firing Mode of CA2 Hippocampal NeuronsNeuronNovember 7, 2018Tirko NN, Eyring KW, Carcea I, Mitre M, Chao MV, Froemke RC, Tsien RW.mouse anti-PV (Swant Cat# PV 25, RRID: AB_10000344, 1:500), rabbit anti-Kv7.3 (KCNQ3; Alomone Cat# APC-051, RRID: AB_2040103, 1:200), mouse anti-RGS14 (Neuromab, 1:100) and rabbit anti-OXTR (Mariela Mitre, Moses

(16) One drug-sensitive subunit is sufficient for a near-maximal retigabine effect in KCNQ channelsThe Journal of general physiologyOctober 1, 2018Yau MC, Kim RY, Wang CK, Li J, Ammar T, Yang RY, Pless SA, Kurata HT.nitrocellulose blots using standard protocols. KCNQ3 protein was probed with a rabbit polyclonal antibody (APC-051; Alomone) and HRP-conjugated mouse anti-rabbit secondary antibody (ABM) and visualized using chemiluminescence

(17) Reduced axonal surface expression and phosphoinositide sensitivity in K_v7 channels disrupts their function to inhibit neuronal excitability in Kcnq2 epileptic encephalopathyNeurobiology of diseaseOctober 1, 2018Kim EC, Zhang J, Pang W, Wang S, Lee KY, Cavaretta JP, Walters J, Procko E, Tsai NP, Chung HJ.ab13970; Cell Signaling 2955S), anti-KCNQ2 (Alomone, APC-050; Neuromab, N26A/23), anti-KCNQ3 (Alomone, APC-051) anti-HA (Covance, MMS-101P, Cell Signaling, 3724 & 2369), anti-CaM (Cell Signaling, 4830), anti-GAPDH

(18) Kv7.3 Compound Heterozygous Variants in Early Onset Encephalopathy Reveal Additive Contribution of C-Terminal Residues to PIP₂-Dependent K⁺ Channel GatingMolecular neurobiologyAugust 1, 2018Ambrosino P, Freri E, Castellotti B, Soldovieri MV, Mosca I, Manocchio L, Gellera C, Canafoglia L, Franceschetti S, Salis B, et al.

(19) Inhibition of striatal cholinergic interneuron activity by the Kv7 opener retigabine and the nonsteroidal anti-inflammatory drug diclofenacNeuropharmacologyJuly 15, 2018Paz RM, Tubert C, Stahl A, Díaz AL, Etchenique R, Murer MG, Rela L.

(20) Functional up-regulation of the M-current by retigabine contrasts hyperexcitability and excitotoxicity on rat hypoglossal motoneuronsThe Journal of physiologyJuly 1, 2018Ghezzi F, Monni L, Nistri A.

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